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Re: T3-acetylcholinerase, testosterone » Larry Hoover

Posted by tealady on September 29, 2003, at 16:36:19

In reply to Re: stuff, and fluoride » tealady, posted by Larry Hoover on September 29, 2003, at 11:58:37

>
> That isn't a coeliac test. It's a test for infection by the Candida family of organisms. Sometimes Candida is associated with e.g. leaky gut syndrome, and may be more prevalent in coeliacs (that's also controversial), but it isn't diagnostic for coeliac itself.

thanks

>
> The blood test I mentioned is for the antibody to gliaden, a gluten protein. If it has entered the blood, it is presumptive that the mechanism involves intestinal injury from gluten, i.e. coeliac sprue.

I'll see if the hospital took those then, probably not..can't get back in til Dec...pity, caus I wanted to ask about the G6PD stuff

>
> > > >
> > > > RT3 normal..right in middle of range, which I also kinda suspected and means I can't put my strange reaction to T4 only meds down to that, unless things have changed in the 2 years since I tried T4 only.

On second thoughts, test taken when only on 20mcg T4 plus thyroid..so still was a higher ratio of T3:T4 than typical human ratios


> >
> > Thyroid hormone resistance is believed to exist I thought..only tested by symptoms, temperature etc though ..don't know a lot about, usually treated (only a few docs WILL treat it)....by high doses of thyroid hormones until non symptomatic
>
> This is one of the issues that is so hard to overcome when dealing with "standard medical practise". Few doctors will treat from symptoms alone. They do a blood test, tell you it's normal (when there is way to much variability in the normal range, in any case), and shrug it off.
>
> I think I need testosterone supps, but I'm going to have a tough time getting it.
>
> > Some folks with this may respond to fish oil??
> > Clear the receptors?
>
> Fish oil increases receptor sensitivity. Possibly also upregulates receptor synthesis.
>
> > Most female hypos find they are low in ferritin and T3 and ferritin work together, and T3 level influences ferritin level.(Men are usually fine with iron.)
>
> Well, there's a lot of weirdness in that too, what with undiagnosed haemochromatosis.

If that's a problem, you could try donating blood fairly often... (I think this may have been why leeches were effective?<g>)

>
> > Been impossible trying to get this up, still not there. Ideal is around 70, should be above 50. ranges wrong..like the B12 tests (I noted iron is involved with the methaemoglobulin stuff too)
>
> Iron malabsorption is charactistic of coeliac, I think.

I did have some stuff on T3/ferritin all together on another board..which closed a couple of weeks ago. I'll dig around and see what I can find and put in another post. Never could really interpret the articles
>
> > B12 and thyroid are linked in there too, some on the PN forum can't get B12 up until took thryoid meds
>
> Thyroid regulates protein synthesis, and as so much of our biochemistry depends on proteins (enzymes are protein, as are receptors, transporters, and blood-transport molecules), that thyroid defects are really systemic insults.
>

interesting

> > Also T3 and acetylcholinerase work together..something I've looked at, with regard to brain function ..unsure of this stuff
>
> The reason fluoride is toxic to thyroid appears to centre around its effects on acetylcholinesterase. The impact is mediated by a host of cofactors, however, but fluorine induces functional zinc deficiency, especially if calcium homestasis is poor, or if iodine deficiency exists. So, given the link of soy and iodine (via genistein), fluorine and soy combined are a thyroid knock-out punch, methinks.
>

Thanks Lar, I know zinc always been the most critical of all my supps (as in bottleneck-critical path)

> Stuff snipped...

In that stuff, sometime have a look at the cortisol article.
I can't figure it out completely, and I know cortisol lowers T3 (also you commented on this), but it's different than just taking less T3..it seems to perhaps lower the T3 by utilizing it? That's how it feels anyway. I was wondering what the article was saying exactly.


>
> > Thyroid hormone actions and membrane fluidity. Blocking action thyroxine on triiodothyronine effect.
> > FEBS Lett. 1977 Dec 1;84(1):199-203. No abstract available.
> > [PubMed - indexed for MEDLINE]
> > PMID: 145376; UI: 78064714.
> > ---------------
> > (not sue what this one about- no abstract available)..assuming RT3 from t4 competing with T3?
> > ---------------------
>
> Well, membrane fluidity is mediated by DHA and EPA (i.e. fish oil), so receptor responsivity seems to have an enhanced response to membrane structure (via an added feedback mechanism). That would be my interpretation.
>
> > I tried going off all meds once last year and onto tyrosine and large supporting supps..I lasted 10 days!before becoming real hypo.
>
> Better to think augmentation rather than replacement, methinks.

well that's the idea this time.


> >
> > EEG went fine, except she said I was too tense but when she asked me to relax I switched to asleep (no surprise there).
>
> You have narcolepsy?

No idea, never got anyone to look at me before.
Just sleeping most of the time..even when pinching myself too say awake. The thyroid meds have helped.

>
> > Apparently people usually don't so this <g>
> > ...guess I must have got the idea sometime Definitely was awake for those lights.
> >
> > Jan
>
> I'd probably not be nodding off, myself. Frankly, my brain would be trying to steal a glimpse of the data, so I could interpret things myself.....heh.

well they make sure you don't do that as they psosition the chair so you can't see the screnn..besides you have to close your eyes <g> and open mouth to relax jaw..then relax

I used to read The Lancet and the New England Journal of Medicine for pleasure.

<g>geek speak beyond me..but I try and interpret the gist of what NEJM articles try to say sometimes.
Re testosterone:
Lar , you ought to sign up for Larrian's newsletter...it's free. Sometimes she gives links to interesting research.
Her background was a urologist,gynae-urologist (s?), and researcher
quit in 96 , due to problems becoming slightly hypothroid..and other stuff..
http://www.goddessdiet.com/Books/DietBook/author.htm
She does tend to see most things as a oestrogen/testosterone problems (or APS type II problems..as this is where she is coming from)..as opposed to someone who may see everything as a magnesium deficiency problem.
Here's her men's message board..not very active at present. She's closed her female ones ..and started a paid private forum, but I think her male one is still going...doesn't look very active.
note- Assumes you've read her diet book. You might be able to get from a library? Probably not a bad read (I think probably the balance is better than Atkin's). It's written in female humour though.
You might pick up some ideas.
http://forums.delphiforums.com/GladiatorDiet/messages/?msg=20.1
I think most of guys use androgel for testosterone replacement.
Hope this doesn't come across as a plug...just something to give an intro to hormonal problems.
You'd be better able to communicate than I ever could. Probably worth your while taking a look at.

Jan


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poster:tealady thread:259730
URL: http://www.dr-bob.org/babble/alter/20030903/msgs/264277.html