Posted by tealady on October 4, 2003, at 12:32:05
In reply to Re: T3-acetylcholinerase, testosterone » tealady, posted by Larry Hoover on October 4, 2003, at 9:22:19
> Hi Jan. Been a rough week. I'll pick these threads back up.
> > > The reason fluoride is toxic to thyroid appears to centre around its effects on acetylcholinesterase. The impact is mediated by a host of cofactors, however, but fluorine induces functional zinc deficiency, especially if calcium homestasis is poor, or if iodine deficiency exists. So, given the link of soy and iodine (via genistein), fluorine and soy combined are a thyroid knock-out punch, methinks.
Hi Lar,
Ya, it's fondly known as fluorosoy on the thyroid forum..I'm in a stupid mood tonight
http://forums.about.com/ab-thyroid/messages?msg=27462.6
http://forums.about.com/ab-thyroid/messages?msg=36280.1 jokes!
> > >
> >
> > In that stuff, sometime have a look at the cortisol article.
> > I can't figure it out completely, and I know cortisol lowers T3 (also you commented on this), but it's different than just taking less T3..it seems to perhaps lower the T3 by utilizing it? That's how it feels anyway. I was wondering what the article was saying exactly.
>
> Can you repost the specific article again?
This is only the abstract? Is that OK? I can probably get the article.Ved HS, et al.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=2473427&dopt=Abstract
Effect of hydrocortisone on myelin basic protein in developing primary brain cultures.
Neurosci Lett. 1989 Apr 24;99(1-2):203-7.
[PubMed - indexed for MEDLINE]
PMID: 2473427; UI: 89314566.
Effect of hydrocortisone on myelin basic protein in developing primary brain cultures.
Ved HS, Gustow E, Pieringer RA
Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140.
The hormones hydrocortisone (HC) and triiodothyronine (T3) are known to regulate myelinogenic parameters in cultures of brain cells. However, the effect of glucocorticoids on the myelin-specific metabolite, myelin basic protein, has not been previously studied. In the present studies we show that the concentrations of myelin basic protein (MBP) in developing primary cultures from mouse cerebra are significantly higher in HC (0.3 microM)-treated as compared to untreated cultures after 15 days in vitro. Further, this effect of HC on MBP appears to be T3-dependent. Since HC stimulates oligodendroglia to produce MBP, the effect of HC on the activities of the enzymes, glutamine synthetase which is primarily associated with astrocytes, and acetylcholinesterase, which is primarily associated with neurons was was determined. HC stimulated both enzymes, suggesting that all 3 cell types may be regulated by HC.
PMID: 2473427, UI: 89314566 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query_old?uid=1699168&form=6&db=m&Dopt=b> > >
> > > You have narcolepsy?
> >
> > No idea, never got anyone to look at me before.
> > Just sleeping most of the time..even when pinching myself too say awake. The thyroid meds have helped.
>
> Two concepts jump out. If narcolepsy, you fall asleep in inappropriate situations....not being tired really, just falling asleep almost at random.hmm. Well I guess if I'm walking or something I don't do that, but I do blank out for a few seconds..like drop a bottle in a supermarket..and only see it when I hear it hit the floor etc. Also I've figured I do this when stressed out a bit and pushing myself(doesn't take much).
The other is poor sleep architecture, awakening without feeling restored, despite adequate "clock time" sleeping. The latter is often helped by meds.....my own turnaround really began when I finally got properly medicated so as to promote restorative sleep. When I don't get that sort of restive sleep, I am very vulnerable to crashing (like I've been struggling with this week).
Me too. Actually I tried going back on Temazepam this week and ended up sleeping say 6 hrs at night,(I'd written on the pack 4.5 hrs..so looks like I'm sleeping longer in one go <g>) then awake 2 hrs..then fighting sleep..give up sleepep another 6 hrs..wake another he..sleep another 4 hrs...
Now tonight..it's 3AM ..I took one (10mg) Temazepam at 8.30Pm..and I'm still wide awake..there was a noisy party acros the road though. I'd never been able to saty awake this late in my life.
I guess if you sleep for 5 days , you need to wake up sometime.
feeling good today..even went for a walk. Beginning to exercise again...just still got the toothache.
>
> > Re testosterone:
>
> > note- Assumes you've read her diet book.>The book is "The Gladiator Diet" she writes for a more general audience ..I'd prefer more detail. I think she mentions the blood tests in there, otherwise you can pick up ideas from a few threads on how to interpret them..or even ask her...everyone does.
Most docs aren't really good at interpreting blood tests..unless it's their field..and they're good in their field.> Besides, I honour the female attributes within me. (Maybe that's what you sensed about me?)
hmmmm well actually It's a dead giveaway that you're male..you'd never get away with posing as a female poster <g>..there's a difference in communication styles, lol.....but if you like
> http://forums.delphiforums.com/GladiatorDiet/messages/?msg=20.1
> > I think most of guys use androgel for testosterone replacement.
>
> My doctor shot that idea down, almost without discussion. If I want the bloodwork, I have to pay out-of-pocket, and if and only if I'm totally out of range will he consider supplementing me.Well you could do what I do..try a different doc??
I've got about 4..and rotate blood tests <g>...I still haven't got the harder to get ones..but hey, even I can get testosterone. But you need a panel.
Re he blood tests...I'm getting to learn what different levels feel like symptomwise, so should be able to taper off soon...it takes a while to learn..for me anyway, with the thyroid levelsOr ask for a referral to a specialist?
If not, one of those guys on that forum is from Canada..he might have some ideas..BTW The reason they use androgel , is that it is easy to titrate, bypasses the liver, and if spread very thinly less conversion to oestradiol.
That's about the limit of my knowledge>
> I know I'm messed up.....it's trying to figger out just where to put my finger on the scales.Lar, when you mentioned testosterone, I wasn't sure if you wanted feed back or not...thought I might have goofed up.
Anyway, IMO I think there's a fair bet from your comments that you are lowish too..and if so that would overwork your adrenals a tad..so they come out a bit stressed out. Once you do get on the testosterone, your adrenals then kinda correct..pretty fast I found with estrogen..caus they don't have to work so hard.
It's just difficult getting it right, but then I think that's caus of this other problem as most, out of hundreds has "got it right" in the end..reckon well over 90%.The comment about the fish oil...I came across what Larrian had told someone about adrenals in someone with pretty good looking blood levels but was feeling their adrenals were stressed out
".....the only other way to deal with your adrenals is to eat a lot of omega fatty acid fish...say 1/2 pounds of salmon twice a week.....tuna....9 hours of sleep....deep breathing techniques...."Interesting , no?
>I'm too early in the investigative process to decide anything. Haven't even ruled out cancer, yet. (the nasties get the first focus, of course, just in case)
Of course, huh?? Hugs, Lar
Fingers crossed, Jan
poster:tealady
thread:259730
URL: http://www.dr-bob.org/babble/alter/20031003/msgs/265521.html