Posted by tealady on September 29, 2003, at 0:01:30
In reply to Re: B12 reaction, NADH, nitrates » tealady, posted by Larry Hoover on September 28, 2003, at 14:41:47
> > BTW , I got some blood tests back this week..no coeliac, (as I expected from an elimination diet years ago. )
>
> That would be the anti-gliadin antibody titre?
Lar below exactly as printed on result form..not a test I'm familiar with
----------------C. Albicans IgA antibodies : negative <10
Candida IgG antibodies (including C.albicans) : Negative <10(C.glabrata, C.parapsilosis and C.tropicalis)
----------------------> >
> > RT3 normal..right in middle of range, which I also kinda suspected and means I can't put my strange reaction to T4 only meds down to that, unless things have changed in the 2 years since I tried T4 only.
>
> Are your thyroid symptoms consistent with the blood concentrations? Sometimes I wonder about the possibility of the thyroid version of insulin resistance.Thyroid hormone resistance is believed to exist I thought..only tested by symptoms, temperature etc though ..don't know a lot about, usually treated (only a few docs WILL treat it)....by high doses of thyroid hormones until non symptomatic
Some folks with this may respond to fish oil??
Clear the receptors?Most female hypos find they are low in ferritin and T3 and ferritin work together, and T3 level influences ferritin level.(Men are usually fine with iron.)
Been impossible trying to get this up, still not there. Ideal is around 70, should be above 50. ranges wrong..like the B12 tests (I noted iron is involved with the methaemoglobulin stuff too)B12 and thyroid are linked in there too, some on the PN forum can't get B12 up until took thryoid meds
Also T3 and acetylcholinerase work together..something I've looked at, with regard to brain function ..unsure of this stuff
Not sure if you are interested in this
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=PubMed enter T3&acetylcholinesterase
OR enter T3&acetylcholinesterase&acetylcholine
--------http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=11440272&dopt=Abstract
Involvement of L-triiodothyronine in acetylcholine metabolism in adult rat cerebrocortical synaptosomes.
. These results predict that T3 stimulates acetylcholine (Ach) metabolism by increasing AchE activity as well as uptake of the released Ach through an increase in synaptosomal Mg2+-ATPase activity.
PMID: 11440272, UI: 21333326
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query_old?uid=8278452&form=6&db=m&Dopt=bTriiodothyronine (T3) modifies cholinergic-induced hypothermia and tremor in rats
Triiodothyronine (T3) modifies cholinergic-induced hypothermia and tremor in rats.
Almeida OM, Santos R
Departamento de Farmacologia e Psicobiologia, Universidade de Estado do Rio de Janeiro, Brasil.
Hypothermia and tremor responses of oxotremorine and eserine were studied in rats after several T3 treatment regimens. The T3 antagonized oxotremorine-induced hypothermia and failed to antagonize eserine hypothermic effect, but potentiated oxotremorine- and eserine-induced tremors. Acetylcholinesterase activity was not altered in T3 rats. The hypothetical mechanisms to explain changes of central cholinergic responses caused by T3 are discussed.
PMID: 8278452, UI: 94105238
Garza R, et al.
Influence of soluble environmental factors on the development of fetal brain acetylcholinesterase-positive neurons cultured in a chemically defined medium: comparison with the effects of L-triiodothyronine (L-T3).
Brain Res Dev Brain Res. 1990 Nov 1;56(2):160-8.
[PubMed - indexed for MEDLINE]
PMID: 2124523; UI: 91084985.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query_old?uid=1699168&form=6&db=m&Dopt=b
Neuroscience 1990;36(2):473-82
Immunocytochemical localization of thyroid hormone nuclear receptors in cultured acetylcholinesterase-positive neurons: a correlation between the presence of thyroid hormone nuclear receptors and L-tri-iodothyronine morphological effects.
Garza R, Puymirat J, Dussault JH
Unite de recherche en Ontogenese et Genetique moleculaire, Centre Hospitalier de l'Universite Laval, Quebec, Canada.
A monoclonal antibody against the rat liver L-tri-iodothyronine nuclear receptor and acetylcholinesterase cytochemistry were used for the localization of thyroid hormone nuclear receptors in acetylcholinesterase-positive cell nuclei in fetal rat cerebral hemisphere neuronal cultures. After 3 days in vitro, the ratio of acetylcholinesterase-positive cells that were immunoreactive for the thyroid hormone nuclear receptor to those not stained for this receptor (74-26%, respectively) remains unchanged despite an increase in the number of acetylcholinesterase-positive cells with time (from day 3 to day 21) in culture. Furthermore, the addition of 3 X 10(-8) L-tri-iodothyronine in culture did not modify this ratio or have an effect on the number of acetylcholinesterase-positive cells, but significantly increased the neurite density in those acetylcholinesterase-positive cells that were immunoreactive for the thyroid hormone receptor. Conversely, no difference in the neurite densities of those acetylcholinesterase-positive cells not stained for this receptor was observed when cultured in the presence or absence of thyroid hormone. In other experiments with the same fetal brain cultures, treatment of cultures for 8 days with L-tri-iodothyronine, beginning on culture day 20, demonstrated the presence of a critical period which occurs in vitro around day 20, since the stimulatory effect of L-tri-iodothyronine on immunoreactive acetylcholinesterase-positive cell neurite density is lost after 20 days in vitro. These results demonstrate, for the first time, the presence of L-tri-iodothyronine nuclear receptors in fetal rat acetylcholinesterase-positive neurons and the existence of a cellular heterogeneity in the distribution of the thyroid hormone receptor. The presence of these receptors in fetal brain acetylcholinesterase-positive neurons suggests that some effects of L-tri-iodothyronine on the maturation of a subpopulation of acetylcholinesterase-positive neurons may result from a direct effect of this hormone through an interaction with its specific nuclear receptors.
PMID: 1699168, UI: 91015748
Ved HS, et al.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=2473427&dopt=Abstract
Effect of hydrocortisone on myelin basic protein in developing primary brain cultures.
Neurosci Lett. 1989 Apr 24;99(1-2):203-7.
[PubMed - indexed for MEDLINE]
PMID: 2473427; UI: 89314566.
Effect of hydrocortisone on myelin basic protein in developing primary brain cultures.
Ved HS, Gustow E, Pieringer RA
Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140.
The hormones hydrocortisone (HC) and triiodothyronine (T3) are known to regulate myelinogenic parameters in cultures of brain cells. However, the effect of glucocorticoids on the myelin-specific metabolite, myelin basic protein, has not been previously studied. In the present studies we show that the concentrations of myelin basic protein (MBP) in developing primary cultures from mouse cerebra are significantly higher in HC (0.3 microM)-treated as compared to untreated cultures after 15 days in vitro. Further, this effect of HC on MBP appears to be T3-dependent. Since HC stimulates oligodendroglia to produce MBP, the effect of HC on the activities of the enzymes, glutamine synthetase which is primarily associated with astrocytes, and acetylcholinesterase, which is primarily associated with neurons was was determined. HC stimulated both enzymes, suggesting that all 3 cell types may be regulated by HC.
PMID: 2473427, UI: 89314566 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query_old?uid=1699168&form=6&db=m&Dopt=b
PDF]REVIEW Thyroid hormone action in mitochondria
http://journals.endocrinology.org/jme/026/0067/0260067.pdf
File Format: PDF/Adobe Acrobat - View as HTML
... systematic study of p43 inter- actions with known ... preprotein translocase of outer
membrane 70, a ... for the calorigenic influence of thyroid hormone (Wrutniak et ...
journals.endocrinology.org/jme/026/0067/0260067.pdf - Similar pages
http://journals.endocrinology.org/jme/026/0067/0260067.pdf-----------------------------------
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=12242684&dopt=Abstract
Banerjee M, et al.
The role of thyroid hormone on phenylhydrazine hydrochloride mediated inhibitory effects on blood acetylcholinesterase: an in vivo and in vitro study.
J Biochem Mol Toxicol. 2002;16(4):162-8.
[PubMed - in process]
PMID: 12242684; UI: 22226722.
seems to imply T3 is more powerful than t4
Lebel JM, et al.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=8146169&dopt=AbstractOverexpression of the beta 1 thyroid receptor induces differentiation in neuro-2a cells.
Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2644-8.
[PubMed - indexed for MEDLINE]
PMID: 8146169; UI: 94195799.
de Mendoza D, et al.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=145376&dopt=AbstractThyroid hormone actions and membrane fluidity. Blocking action thyroxine on triiodothyronine effect.
FEBS Lett. 1977 Dec 1;84(1):199-203. No abstract available.
[PubMed - indexed for MEDLINE]
PMID: 145376; UI: 78064714.
---------------
(not sue what this one about- no abstract available)..assuming RT3 from t4 competing with T3?
---------------------I tried going off all meds once last year and onto tyrosine and large supporting supps..I lasted 10 days!before becoming real hypo.
If I figure it all out, I'm trying again..but this time very slow taper, not cold turkey...learnt more since then
I still have some other problem obviously, and at present need the thyroid hormones to keep me going.
>
> > I did suspect a small reaction to nitrates years ago in an elimination diet, and I've always limited this..occasionally bacon or corn beef seemed OK though.
> > It fits in with that dental injection reaction and B12 reaction.
> > That week I did eat a lot of nitrates so may have built up my level of (lot of leftover corn beef dinner that I froze and too lazy to prepare new food err preferring to spend time on the net?)Also fits with the oxygen comments I've made, and low ferritin levels.
EEG went fine, except she said I was too tense but when she asked me to relax I switched to asleep (no surprise there).
Apparently people usually don't so this <g>
...guess I must have got the idea sometime Definitely was awake for those lights.Jan
poster:tealady
thread:259730
URL: http://www.dr-bob.org/babble/alter/20030903/msgs/264169.html