Posted by tealady on September 27, 2003, at 19:16:25
In reply to Re: B12 reaction » tealady, posted by Larry Hoover on September 21, 2003, at 5:55:12
>
> > Just wondered if you had heard of any connection between B12 and numbness and tingling"
>
> No. And I can't find anything that even gives me a hint.Me either ..nor had anyone on a peripheral neuropathy board
B12 supposed to fix the PN, not exasperate it.
(The PN started after about 4 weeks on T4 only meds which is why I dropped it..another story, about 2 years ago.)
> > After each B12 needle I'd have a "one step backwards, two steps forwards reaction"...I was hoping I was doing the right thing, but the trend line seem to be on the improve. Each injection the "purple" lessened and the colour of feet/hands turned brighter red
>>
> That actually suggests to me that you were seriously B12 deficient, and that your body had ramped up some enzyme concentrations in a desperate attempt to accommodate what little B12 you had available. That's my educated guess.If it was an allergy, you'd get worse over time, not better. You'd have hives. And you'd have a more severe reaction at the injection site.
Your right..haven't had hives since I was 12! lots around that age.
No it definitely was not an allergic reaction, although I'm going to check on any preservatives later today as Joebob suggested (the Australian drug reference I used to use has been removed from the net in the past month or so,sigh). I'm usually very careful about preservatives though.>
> > Also methylcobalamin sublinguals have similar but far weaker reactions.
>
> Suggesting you don't have good gut uptake of B12, consistent with the idea that you were previously seriously deficient in B12.
Lar, they were sublinguals..so does this gut uptake still apply that much? I do understand the poor gut uptake from diet, which most my life was a high protein meat diet style diet..mentioned b4 how I was always craving meat ..>You do sound like you might benefit from NADH. Enada is the company that patented the process, but they license the product to numerous vendors. I would presume there is an Aussie vendor.
No. I can only get niacinamide and niacin.
I'm going to order the NADH from o'seas. .I had tried all the chemists before your suggestion. This week I've tried all the docs I can think of who practise some kind of orthomolecular psychiatry or on some nutritional basis..in case they resell some ..but I have found none. Most only suggest dietary modifications and supps like niacinamide.. etc.. (docs in Oz don't list their specialty..so It's difficult to find out..dumb idea in my book).Is the sublingual OK for the NADH?(or should I look for an enteric coated one).
I was thinking of ordering these ones http://store.yahoo.com/iherb/enadasn25.html
BTW , I got some blood tests back this week..no coeliac, (as I expected fdrom an alimination diet years ago. )
Probably glandular fever a long time ago(about 20 yrs I suspect)..which they believe can trigger hashi.
I didn't really want either of these run, but guess nice to know.RT3 normal..right in middle of range, which I also kinda suspected and means I can't put my strange reaction to T4 only meds down to that, unless things have changed in the 2 years since I tried T4 only.
I did suspect a small reaction to nitrates years ago in an elimination diet, and I've always limited this..occasionally bacon or corn beef seemed OK though.
It fits in with that dental injection reaction and B12 reaction.
That week I did eat a lot of nitrates so may have built up my level of (lot of leftover corn beef dinner that I froze and too lazy to prepare new food err preferring to spend time on the net?)
Here's
http://www.health.qld.gov.au/phs/Documents/ehu/4599.pdf
people with a deficiency of a particular enzyme (glucose-6-phosphate dehydrogenase) are at particular risk from the ingestion of
high levels of nitrate and nitrite.
Even higher levels of exposure are needed to cause adverse health effects in other people. The adverse health effects are attributed to the formation of methaemoglobin. This compound is formed when nitrite present in the blood binds to normal haemoglobin.
If the level of methaemoglobin in the blood is too high, a person may exhibit symptoms suggestive of not having enough oxygen because
methaemoglobin does not carry oxygen as efficiently as normal haemoglobin. The types of symptoms are related to the level of
methaemoglobin in the blood.
Symptoms may include bluish discolouration of the skin, particularly around the mouth and eyes, headache, dizziness, weakness and difficulty in breathing. In most severe cases damage to the brain and even death may occur.
The conversion of haemoglobin to methaemoglobin requires nitrite.
However, ingested nitrate can be converted to nitrite by bacteria normally present in the stomach. In most people, methaemoglobin is
converted back to haemoglobin, but low levels of methaemoglobin are normally present and do not pose a risk to health.
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So can I please borrow your brain hon on
glucose-6-phosphate dehydrogenase?How's your elimination diet going?
<fried brain? Hugs,
Jan
poster:tealady
thread:259730
URL: http://www.dr-bob.org/babble/alter/20030903/msgs/263813.html