Posted by Larry Hoover on October 8, 2003, at 7:49:47
In reply to Re: T3-acetylcholinerase, testosterone » Larry Hoover, posted by tealady on October 4, 2003, at 12:32:05
> > > I can't figure it out completely, and I know cortisol lowers T3 (also you commented on this), but it's different than just taking less T3..it seems to perhaps lower the T3 by utilizing it? That's how it feels anyway. I was wondering what the article was saying exactly.
> >
> > Can you repost the specific article again?
> This is only the abstract? Is that OK? I can probably get the article.
>
> Ved HS, et al.
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=2473427&dopt=Abstract
> Effect of hydrocortisone on myelin basic protein in developing primary brain cultures.
> Neurosci Lett. 1989 Apr 24;99(1-2):203-7.
> [PubMed - indexed for MEDLINE]
> PMID: 2473427; UI: 89314566.
> Effect of hydrocortisone on myelin basic protein in developing primary brain cultures.
> Ved HS, Gustow E, Pieringer RA
> Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140.
> The hormones hydrocortisone (HC) and triiodothyronine (T3) are known to regulate myelinogenic parameters in cultures of brain cells. However, the effect of glucocorticoids on the myelin-specific metabolite, myelin basic protein, has not been previously studied. In the present studies we show that the concentrations of myelin basic protein (MBP) in developing primary cultures from mouse cerebra are significantly higher in HC (0.3 microM)-treated as compared to untreated cultures after 15 days in vitro. Further, this effect of HC on MBP appears to be T3-dependent. Since HC stimulates oligodendroglia to produce MBP, the effect of HC on the activities of the enzymes, glutamine synthetase which is primarily associated with astrocytes, and acetylcholinesterase, which is primarily associated with neurons was was determined. HC stimulated both enzymes, suggesting that all 3 cell types may be regulated by HC.
> PMID: 2473427, UI: 89314566 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query_old?uid=1699168&form=6&db=m&Dopt=bSimply put, deficiencies in either hydrocortisone or T3 will block proper development of neurons (particularly their ability to fire appropriately). Given that we now know that the adult brain can still generate new neurons, and new connections between them, cognitive defects will be likely if adrenal function (source of HC), thyroid hormone synthesis (T4), or thyroid hormone deiodination (to make T3) is/are messed up.
> > Two concepts jump out. If narcolepsy, you fall asleep in inappropriate situations....not being tired really, just falling asleep almost at random.
>
> hmm. Well I guess if I'm walking or something I don't do that, but I do blank out for a few seconds..like drop a bottle in a supermarket..and only see it when I hear it hit the floor etc. Also I've figured I do this when stressed out a bit and pushing myself(doesn't take much).That sounds more like epilepsy.
> > The other is poor sleep architecture, awakening without feeling restored, despite adequate "clock time" sleeping. The latter is often helped by meds.....my own turnaround really began when I finally got properly medicated so as to promote restorative sleep. When I don't get that sort of restive sleep, I am very vulnerable to crashing (like I've been struggling with this week).
>
> Me too. Actually I tried going back on Temazepam this week and ended up sleeping say 6 hrs at night,(I'd written on the pack 4.5 hrs..so looks like I'm sleeping longer in one go <g>) then awake 2 hrs..then fighting sleep..give up sleepep another 6 hrs..wake another he..sleep another 4 hrs...
> Now tonight..it's 3AM ..I took one (10mg) Temazepam at 8.30Pm..and I'm still wide awake..there was a noisy party acros the road though. I'd never been able to saty awake this late in my life.
> I guess if you sleep for 5 days , you need to wake up sometime.Still, the key concept is restorative, rather than duration. If you feel better after using the temazepam, you may find a cumulative benefit if you use it for a period of time. I certainly did.
> feeling good today..even went for a walk. Beginning to exercise again...just still got the toothache.
Take an analgesic, eh?
> > > I think most of guys use androgel for testosterone replacement.
> >
> > My doctor shot that idea down, almost without discussion. If I want the bloodwork, I have to pay out-of-pocket, and if and only if I'm totally out of range will he consider supplementing me.
>
> Well you could do what I do..try a different doc??That's just not possible. There's a doctor shortage, such that 20% of people do not even have a regular doctor. You can't switch. Referrals to specialists must be generated by your regular doctor, so I either get help or I don't.
> I've got about 4..and rotate blood tests <g>...I still haven't got the harder to get ones..but hey, even I can get testosterone. But you need a panel.
I gonna pay for the blood work. I want information.
> Re he blood tests...I'm getting to learn what different levels feel like symptomwise, so should be able to taper off soon...it takes a while to learn..for me anyway, with the thyroid levels
>
> Or ask for a referral to a specialist?If and only if one of my hormones is out of range, and given the order of magnitude (or larger) reference range for many hormones, I doubt I'll get the evidence I need.
> If not, one of those guys on that forum is from Canada..he might have some ideas..
Thanks for the link.
> BTW The reason they use androgel , is that it is easy to titrate, bypasses the liver, and if spread very thinly less conversion to oestradiol.
> That's about the limit of my knowledgeThe gel is definitely the way to go.
> >
> > I know I'm messed up.....it's trying to figger out just where to put my finger on the scales.
>
> Lar, when you mentioned testosterone, I wasn't sure if you wanted feed back or not...thought I might have goofed up.I wouldn't have mentioned it if I was concerned about other people's ideas, or my own privacy.
> Anyway, IMO I think there's a fair bet from your comments that you are lowish too..and if so that would overwork your adrenals a tad..so they come out a bit stressed out.I've believed I have adrenal fatigue for years now. Couldn't get help with that, either.
> Once you do get on the testosterone, your adrenals then kinda correct..pretty fast I found with estrogen..caus they don't have to work so hard.
Maybe if I win the lottery, I can go to the States and buy the care I want. :-/
> It's just difficult getting it right, but then I think that's caus of this other problem as most, out of hundreds has "got it right" in the end..reckon well over 90%.
If only androgel was OTC.
> The comment about the fish oil...I came across what Larrian had told someone about adrenals in someone with pretty good looking blood levels but was feeling their adrenals were stressed out
> ".....the only other way to deal with your adrenals is to eat a lot of omega fatty acid fish...say 1/2 pounds of salmon twice a week.....tuna....9 hours of sleep....deep breathing techniques...."
>
> Interesting , no?Fits with my understanding.
> >I'm too early in the investigative process to decide anything. Haven't even ruled out cancer, yet. (the nasties get the first focus, of course, just in case)
>
> Of course, huh?? Hugs, Lar
>
> Fingers crossed, JanFirst tests today.
Thanks for the support.
Lar
poster:Larry Hoover
thread:259730
URL: http://www.dr-bob.org/babble/alter/20031003/msgs/266679.html