Posted by SLS on December 17, 2010, at 4:48:50
In reply to Re: Why do I feel like jumping off a bridge? » SLS, posted by Maxime on December 16, 2010, at 20:59:52
Hi Maxime.
> Hi Scott, I already take 600 mg of Trileptal. I don't feel like more would help. As for the Nortrip. I still can decide what to do. I would like try the Desipramine for I think. I don't know. I don't feel like anything can help me now.
Read the abstract below. Interesting. Is there any chance that you are feeling worse because of Trileptal? Although this might not be a ubiquitous side effect, the potential for increased depression cannot be overlooked. Just like with traditional antidepressants, some people will experiencing a worsening of depression with some anticonvulsant drugs, but not others. There is more mention in the medical literature in favor of the use of oxcarbazepine for depression than there are contraindications. The drug does display antidepression-like behavioral effects according to some rat studies, and is theorized to increase DA and NE neurotransmission.
The combination of lithium and oxcarbazepine tends to work better than lithium alone to treat acute mania in bipolar disorder. Less is known about the statistical rate of success treating depression. If you suspect that an exacerbation of depression is linked to your taking oxcarbazepine, I would not recommend discontinuing it right now. A thorough discussion with your doctor should precede any self-medication that you may be tempted to perform.
I took oxcarbazepine for quite a few weeks. If anything, I found it mildly stimulating and not at all exacerbating of depression.
Have you tried the following drugs?
Topiramate(Topamax)
Clonazepam (Klonopin)
Lithium?
Sertraline (Zoloft)
- Scott
----------------------------------Neurology. 2010 Jul 27;75(4):335-40.
Use of antiepileptic drugs in epilepsy and the risk of self-harm or suicidal behavior.Andersohn F, Schade R, Willich SN, Garbe E.
Institute for Social Medicine, Epidemiology and Health Economics, Charité-University Medical Center, Berlin, Germany. frank.andersohn@charite.de
Comment in:
* Neurology. 2010 Jul 27;75(4):e12-5.
* Neurology. 2010 Jul 27;75(4):300-1.Abstract
BACKGROUND: A recent meta-analysis of randomized trials revealed that antiepileptic drugs (AEDs) as a class increase the risk of suicidal thoughts and behavior. We conducted an observational study with data from the United Kingdom General Practice Research Database to investigate if an increase in risk for different groups of AEDs is also evident in clinical practice.
METHODS: This was a nested case-control study in a cohort of 44,300 patients with epilepsy who were treated with AEDs. Patients with self-harm or suicidal behavior were identified by predefined codes. We included 453 cases and 8,962 age-matched and sex-matched controls. AEDs were classified into 4 groups: barbiturates, conventional AEDs, and newer AEDs with low (lamotrigine, gabapentin, pregabalin, oxcarbazepine) or high (levetiracetam, tiagabine, topiramate, vigabatrin) potential of causing depression. Adjusted odds ratios (OR) were calculated using conditional logistic regression.
RESULTS: Current use of newer AEDs with a high potential of causing depression was associated with a 3-fold increased risk of self-harm/suicidal behavior (OR = 3.08; 95% [CI] 1.22-7.77) as compared with no use of AEDs during the last year. Use of barbiturates (OR = 0.66; 95% CI 0.25-1.73), conventional AEDs (OR = 0.74; 95% CI 0.53-1.03), or low-risk newer AEDs (OR = 0.87; 95% CI 0.47-1.59) was not associated with an increased risk.
CONCLUSIONS: Newer AEDs with a rather high frequency of depressive symptoms in clinical trials may also increase the risk of self-harm or suicidal behavior in clinical practice. For the most commonly used other groups of AEDs, no increase in risk was observed.
PMID: 20660863 [PubMed - indexed for MEDLINE]
Some see things as they are and ask why.
I dream of things that never were and ask why not.
poster:SLS
thread:970034
URL: http://www.dr-bob.org/babble/20101203/msgs/973772.html