Posted by sowhysosad on May 22, 2009, at 6:35:02
In reply to Re: Avoid serotonergics after bad SRI reaction?, posted by newquestions on May 21, 2009, at 15:51:09
But the prior adaptation would be one of DE-sensitisation of the 5HT receptors, not hypersensitivity.
Although I guess they'll upregulate after removing the first SRI, perhaps rendering them too sensitive for a second one.
> I think it goes like this: years of SSRI use leads to body adaption, person goes off SSRI either because of side effects or because they are sick of being on SSRIs, person gets depressed and so tries to reintroduce SSRI, body rejects it because of prior adaptation which is the bad reaction/hypersensitivity.
poster:sowhysosad
thread:896671
URL: http://www.dr-bob.org/babble/20090515/msgs/897091.html