Posted by SLS on May 22, 2009, at 9:58:50
In reply to Re: Avoid serotonergics after bad SRI reaction?, posted by newquestions on May 22, 2009, at 9:41:32
> Perhaps the receptors are desenitized, but there are less of them, so there is less need for med to stimulate them?
Downregulation and upregulation of these receptors are determined by receptor numbers rather than binding affinity.
> I became supersensitive while on the SSRI--I never did an abrupt discontinuation.
When I referenced the withdrawal syndrome, I meant to portray a way for kindling during withdrawal episodes to produce progressively intense and protracted discontinuation effects. If this is accurate, then it is imperative to follow a discontinuation protocol to minimize the occurrence of the withdrawal syndrome from the very first drug discontinuation.
- Scott
poster:SLS
thread:896671
URL: http://www.dr-bob.org/babble/20090515/msgs/897098.html