Posted by sowhysosad on May 20, 2009, at 18:37:57
In reply to Re: Avoid serotonergics after bad SRI reaction? » sowhysosad, posted by SLS on May 20, 2009, at 7:10:25
Fascinating stuff Scott - thanks so much.
I'm actually starting to think that my glutamate function may be compromised rather than over-active. I mentioned elsewhere that I have a noticeable improvement in mood after eating MSG-heavy food.
Also, my depression got significantly worse on imipramine and then improved dramatically after quitting it. Earlier I found this piece of research:
> > > Look into "kindling". Kindling might be operating as the result of the overactivity of certain neural pathways (perhaps glutamatergic) that produce severe side effects. Kindling would account very nicely for subsequent hypersensitivity to these drugs with regard to side effects.
> >
> > I just remembered - in another thread bleauberry was speculating that a large dose of MSG in a Chinese meal may have amplified the effects of some 5-HTP I took. But bleau says this would point to REDUCED glutamate function rather than overactivity.
> >
> > What would this tell us in the light of your theory above?
> >
> > Either way, it looks like glutamate function could be a factor in why I've been feeling so screwed up over the past 8 months, so I'd really appreciate any pointers you can give me Scott!
>
>
> 1. lamotrigine (Lamictal)
> 2. memantine (Namenda)
> 3. topiramate (Topamax)
>
> All three drugs reduce glutamatergic neurotransmission, each using a different mechanism.
>
> The price is prohibitive, but riluzole (Rilutek) is another antiglutamtergic drug.
>
> Other anti-kindling drugs that work through sodium channel inhibition
>
> Na+ channel inhibition > pro-GABA > anti-glutamate:
>
> 1. valproate (Depakote)
> 2. oxcarbazepine (Trileptal)
>
> Gabapentin (Neurontin) is a calcium receptor antagonist (alpha-2-delta subunit). I don't know if it would help.
>
> Tiagabine (Pregabalin) is a GABA reuptake inhibitor with anti-kindling properties. It might help, but I feel the drug is unpredictable. Lower dosages might be the way to go with this drug.
>
>
> - Scott
poster:sowhysosad
thread:896671
URL: http://www.dr-bob.org/babble/20090515/msgs/896853.html