Posted by SLS on May 20, 2009, at 15:06:26
In reply to Re: Avoid serotonergics after bad SRI reaction? » newquestions, posted by SLS on May 20, 2009, at 10:50:40
> > I would argue that the adverse reaction was caused by a new hypersensitivity to the SRI based on prior years of use and that you needed to go off the SRI anyway...
>
> No need to argue. We really are in agreement. The mechanism by which someone becomes hypersensitive to SRI may or may not be due to DOWNSTREAM glutamatergic hyperactivity produced by chronic use of these drugs. However to understand this as a kindling process makes sense to me.I almost forgot. I think one of the things that kindling might be responsible for is a worsening of withdrawal effects, either as an unusually protracted period of withdrawal after chronic exposure to the drug or progressively more severe withdrawal effects as the result of repeated drug discontinuations.
- Scott
poster:SLS
thread:896671
URL: http://www.dr-bob.org/babble/20090515/msgs/896842.html