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Re: Avoid serotonergics after bad SRI reaction? » sowhysosad

Posted by SLS on May 20, 2009, at 22:11:33

In reply to Re: Avoid serotonergics after bad SRI reaction?, posted by sowhysosad on May 20, 2009, at 18:37:57

Glutamate does not normally cross the blood-brain barrier in humans. However, MSG has been shown to destroy nerve cells when fed to young animals.

How does coffee (caffeine) affect you? If you had overactive glutamatergic activity, I imagine you would feel very uncomfortable taking caffeine - dysphoria and anxiety. Caffeine is an adenosine receptor blocker. Normally, the stimulation of these receptors helps put the brakes on glutamatergic activity as it is an inhibitory modulator. With these receptors being blocked, glutamate activity might run amok in certain individuals. This is all guesswork on my part. I have yet to form a hypothesis of what one's reaction to caffeine would be if they were chronically hypoactive as you believe you might be. There is just too much about glutamate dynamics that I don't understand. I am looking forward to hearing how caffeine affects you.


- Scott

 

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