Posted by Quintal on March 30, 2008, at 16:14:29
In reply to Re: Parnate metabolites » Britney27, posted by Larry Hoover on March 30, 2008, at 13:55:29
I'm not sure what to make of the tone of your own post Larry... People regularly post of high-dose parnate use, in fact it's quite rare to hear of a long-term user taking a dose within the recommeneded UK limit of 30mg, and I've remarked on this before. Still, I don't remember anyone being repremanded for 'foolhardy' behaviour in the past - indeed most people are prescribed these doses under the supervision of their doctor. As someone who has actually taken it, I don't consider high-dose Parnate any more reckless or foolhardy than combining Nardil with stimulants or TCAs, which we often read about here. Some people only acheive an adequate therapeutic response at higher doses. 30mg only made me feel agitated and suicidal - a dangerous combination as any, while 80-120mg gave me the best response I've ever had to any antidepressant. I'm not personally bothered by addiction. Most of the drugs that have actually worked for me have been addictive.
I think this might be the autopsy report I read a while ago:
__________________________________________________1: Forensic Sci Int. 1997 Apr 18;86(1-2):103-8.Click here to read Links
The GCMS analysis of tranylcypromine (Parnate) in a suspected overdose.
Crifasi J, Long C.Saint Louis University Medical School, Department of Pathology, Berkeley, Missouri 63134, USA.
A fatal overdose involving tranylcypromine (Parnate) where blood, urine and tissues were quantitated using a pentafluoroproprionic anhydride (PFPA) derivative and gas-chromatography/mass spectroscopy (GCMS). The samples were re-quantified over several weeks demonstrating a significant loss of drug in tissues but not blood or urine specimens. The urine was positive for methamphetamine which has been a suspected metabolite.
PMID: 9153786 [PubMed - indexed for MEDLINE]
__________________________________________________I did wonder if the victim may have been a methamphetamine user, but the authors seem to lean towards the metabolite theory to account for its presence in the urine. Without more information there's no way of knowing for sure. There were other sources supporting the methamphetamine theory, as well as a study or two finding no amphetamine metabolites. I don't have the energy to weed them all out right now. As you say, Parnate has not been extensively researched and some of the material is contradictory.
>Chasing the stimulant effect through dose increases inevitably endangers life...
I think that's an exaggeration.
>High dose tranycylpromine can produce thrombocytopenia (loss of blood clotting), and hyperpyrexia (temperature spike). I wouldn't risk those consequences for anything.
High dose fish oil and vitamin E can also drastically reduce blood clotting, as I found myself (torrential nosebleeds). I'm not unduly alarmed - sometimes it's worth the risk. I remember Lexapro used to give me pyrexia. I thought it was just one of those things you had to put up with. I had neither of those problems while on high-dose Parnate though.
Q
poster:Quintal
thread:819514
URL: http://www.dr-bob.org/babble/neuro/20080204/msgs/820716.html