Posted by Larry Hoover on March 30, 2008, at 16:37:56
In reply to Re: Parnate metabolites, posted by Quintal on March 30, 2008, at 16:14:29
P.S.
With respect to methamphetamine as a potential metabolite of tranylcypromine......
The only way this could arise is if the cyclopropane ring to which the amine group is attached is opened. Two possible products of the ring-opening might arise, one of which is amphetamine, which could potentially serve as a necessary intermediate to methamphetamine. However, intensive metabolic studies have failed to show that either of these two intermediate metabolites are, in fact, produced. Methamphetamine would require the addition of CH5, i.e. a combined methylation/hydrogenation reaction which also opens that same ring, and I know of no reasonable way to effect that reaction, even in the laboratory. If there's no evidence for the production of amphetamine, then methamphetamine production is quite out of the question.
Lar
poster:Larry Hoover
thread:819514
URL: http://www.dr-bob.org/babble/neuro/20080204/msgs/820724.html