Posted by britney27 on March 24, 2008, at 8:44:41
In reply to Re: Parnate LD 50 [xxx]? » britney27, posted by Larry Hoover on March 24, 2008, at 8:19:01
> > Dear Larry, where did you get the gsk less XXXmg from? I tried to obtain that info on the internet but can't find it?
>
> If you Google tranylcypromine and MSDS, it'll be on the first page.
>
> > What does that exactly mean anyway, does it mean anything less than XXXmg a day is safe?
> >
> > cheers
> >
> > Britney
>
> There are a number of interpretive issues to consider. First, the toxic amount is stated in ambiguous terms. Less than XXX? How much less? I don't recall seeing a vague statement like that one on an MSDS, ever before. Also, this figure is for another species, not even in the same Order as we are, i.e. not from a primate. Generalizing toxicity from this vague information is risky.
>
> But that's why I focussed on the symptoms of toxicity. Frankly, it doesn't matter one iota what the statistical dose for toxicity happens to be, when one individual is making that personal assessment of toxicity. 10,000 other people might get away with taking a particular dose, but if it creates symptoms of toxicity in *you*, then that's all that matters. For you, that's all that matters.
>
> LarHi Larry, your original suggetion of less than xxxmg/kg does not refer to Tranylcypromine (parnate). My original figure was correct. Double that for full toxicity (ref Goldfranks Toxicologic emergencies). I think you were mistaken with moclobemide, another MAOI but reversible which is much much higher saftey threshold, the same amount that you suggested. I know rats are different primates but they do behave similarily to humans.
I agree with you though that knowing the symptoms of toxicity is important but even then it gets confusing because I have had some of those symptoms before and told the chemist and she said it was normal side-effects, so knowing hte safest maximum dose is still an important indicator for responsible consumption. Thanks so much for your reply though, I really do appreciate the fact that you replied to my question.
cheers
Britney
poster:britney27
thread:819514
URL: http://www.dr-bob.org/babble/neuro/20080204/msgs/819636.html