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Re: Atomoxetine helping - fingers crossed undopaminergic

Posted by linkadge on June 21, 2020, at 17:29:26

In reply to Re: Atomoxetine helping - fingers crossed, posted by undopaminergic on June 21, 2020, at 8:48:08

>But does binding to these "alternative" site(s) >prevent the DAT from binding dopamine?

Probably, put perhaps with greater selectivity for certain brain regions over other brain regions. There may too be differences in the binding kinetics (i.e. how quickly DAT is inhibited or the maximum inhibition). I have no idea.

>Maybe to a certain degree that is less than >classic DATIs? Could eg. cocaine + benztropine >have additive effects?

I remember reading that analogues of benztropine were being investigated for treatment of cocaine addiction. I.e. for their ability to reduce certain withdrawal symptoms but not producing much euphoria by themselves. Benztropine can be abused, but I don't know if it is more due to it's anticholinergic properties.


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poster:linkadge thread:1110783
URL: http://www.dr-bob.org/babble/20200511/msgs/1110919.html