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Re: Atomoxetine helping - fingers crossed SLS

Posted by undopaminergic on June 20, 2020, at 5:06:18

In reply to Re: Atomoxetine helping - fingers crossed undopaminergic, posted by SLS on June 19, 2020, at 19:55:41

> > Modafinil is supposedly a central alpha1B-adrenoceptor *agonist*, hence purportedly its "eugeroic" effects, as separate from its stimulant action.
>
>
> Modafinil has always been a bit of an enigma. First, it was dopamine reuptake inhibition. Then, it was orexin activation. It turns out that orexin is more important for alertness / cognition than it is for wakefullness.
>
> "Modafinil-induced wakefulness can be attenuated by the alpha-1 adrenergic antagonist, prazosin, which led to the initial conclusion that modafinil stimulates the central alpha-1 adrenergic system. However, in vitro assay systems responsive to alpha-adrenergic stimulation have not shown that modafinil is a direct or indirect alpha-1 adrenergic agonist."
>
>
> https://www.wellrx.com/modafinil/monographs/
>
>
> - Scott

The dopamine transporter binding of modafinil has been ascertained, including proven essential for its effects. I don't know about other actions. It would be ironic if the atypical stimulant profile of modafinil were due to the *lack* of noradrenergic actions, ie. selectivity for dopamine.

-undopaminergic


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URL: http://www.dr-bob.org/babble/20200511/msgs/1110870.html