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Re: Atomoxetine helping - fingers crossed PeterMartin

Posted by linkadge on July 2, 2020, at 17:23:53

In reply to Re: Atomoxetine helping - fingers crossed, posted by PeterMartin on July 1, 2020, at 23:43:14

Yeah, do watch this combination.

Although atomoxetine is (on paper) an NRI, I remember reading that in vivo (in higher doses) it can begin to occupy the serotonin transporter (as the norepinephrine transporter becomes saturated).

There was a study in primates suggesting that in the 1-2 mg/kg range there was a notable inhibition of serotonin transporters.

https://pubmed.ncbi.nlm.nih.gov/23933039/

At 18mg, I don't think there would be an issue, but I would raise the dose more slowly / cautiously beyond that.

Linkadge


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