Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Atomoxetine helping - fingers crossed undopaminergic

Posted by SLS on June 19, 2020, at 19:55:41

In reply to Re: Atomoxetine helping - fingers crossed SLS, posted by undopaminergic on June 19, 2020, at 11:31:31

> Modafinil is supposedly a central alpha1B-adrenoceptor *agonist*, hence purportedly its "eugeroic" effects, as separate from its stimulant action.

Modafinil has always been a bit of an enigma. First, it was dopamine reuptake inhibition. Then, it was orexin activation. It turns out that orexin is more important for alertness / cognition than it is for wakefullness.

"Modafinil-induced wakefulness can be attenuated by the alpha-1 adrenergic antagonist, prazosin, which led to the initial conclusion that modafinil stimulates the central alpha-1 adrenergic system. However, in vitro assay systems responsive to alpha-adrenergic stimulation have not shown that modafinil is a direct or indirect alpha-1 adrenergic agonist."

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




Post a new follow-up

Your message only Include above post

Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.


Start a new thread

Google www
Search options and examples
[amazon] for

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:SLS thread:1110783