Posted by SLS on June 19, 2020, at 19:55:41
In reply to Re: Atomoxetine helping - fingers crossed » SLS, posted by undopaminergic on June 19, 2020, at 11:31:31
> Modafinil is supposedly a central alpha1B-adrenoceptor *agonist*, hence purportedly its "eugeroic" effects, as separate from its stimulant action.
Modafinil has always been a bit of an enigma. First, it was dopamine reuptake inhibition. Then, it was orexin activation. It turns out that orexin is more important for alertness / cognition than it is for wakefullness."Modafinil-induced wakefulness can be attenuated by the alpha-1 adrenergic antagonist, prazosin, which led to the initial conclusion that modafinil stimulates the central alpha-1 adrenergic system. However, in vitro assay systems responsive to alpha-adrenergic stimulation have not shown that modafinil is a direct or indirect alpha-1 adrenergic agonist."
https://www.wellrx.com/modafinil/monographs/
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.The only thing necessary for the triumph of evil is that good men do nothing.
poster:SLS
thread:1110783
URL: http://www.dr-bob.org/babble/20200511/msgs/1110862.html