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Re: Atomoxetine helping - fingers crossed

Posted by PeterMartin on July 3, 2020, at 3:20:25

In reply to Re: Atomoxetine helping - fingers crossed PeterMartin, posted by linkadge on July 2, 2020, at 17:23:53

> Yeah, do watch this combination.
>
> Although atomoxetine is (on paper) an NRI, I remember reading that in vivo (in higher doses) it can begin to occupy the serotonin transporter (as the norepinephrine transporter becomes saturated).
>
> There was a study in primates suggesting that in the 1-2 mg/kg range there was a notable inhibition of serotonin transporters.
>
> https://pubmed.ncbi.nlm.nih.gov/23933039/
>
> At 18mg, I don't think there would be an issue, but I would raise the dose more slowly / cautiously beyond that.
>
> Linkadge

Hmm....this is a little scary actually. Is there ever a situations where serotonin is increased in some parts of the brain w.o. potentially causing SS?

Maybe I should quit while I'm ahead. Meh.

I wish I did better w desipramine. It gave me massive sweating....and I was also somewhat concerned about the possibility of mania w. It being a TCA and me having bp1 (although only been manic when pot was involved).


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poster:PeterMartin thread:1110783
URL: http://www.dr-bob.org/babble/20200511/msgs/1111125.html