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Re: Atomoxetine helping - fingers crossed SLS

Posted by undopaminergic on June 19, 2020, at 11:31:31

In reply to Re: Atomoxetine helping - fingers crossed, posted by SLS on June 19, 2020, at 8:14:26

>
> Prazosin blocks several types of NE alpha-1 receptors in the brain. My favored explanation is that its positive effects are due to NE alpha-1b antagonism.
>

Modafinil is supposedly a central alpha1B-adrenoceptor *agonist*, hence purportedly its "eugeroic" effects, as separate from its stimulant action. In my understanding, alpha1B is more sensitive to adrenaline than noradrenaline. Although adrenaline from the adrenal medulla does not cross the BBB, there are PNMT-positive neurons in the CNS.

(PNMT is the final enzyme in the chain of L-dopa -> ... -> adrenaline synthesis.)

-undopaminergic


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URL: http://www.dr-bob.org/babble/20200511/msgs/1110836.html