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Re: does anyone know about GABA receptors

Posted by undopaminergic on April 14, 2020, at 7:26:24

In reply to Re: does anyone know about GABA receptors, posted by linkadge on April 13, 2020, at 13:02:14

> >dopamine in the nucleus accumbens (NAc) are >inhibitory, or in other words, the VTA dopaminergic >neurons inhibit the shell of the NAc to produce its >rewarding effects.
>
> Right. Research points to the notion that dopamine is more involved in reward anticipation, rather than reward itself.
>

I agree it is mostly anticipatory. The emotion it produces can be called "desire" or "wanting"; desire to pursue something perceived as rewarding. With stimulants, there is no increase in consummatory reward ("liking", "enjoying"). However, the desire (or "lust" or "enthusiasm") *is* rewarding in its own right.

That said, pramipexole was anti-anhedonic for me. I enjoyed music, food, and movies, in a way I hadn't since the depression started and until I tried pramipexole; and I do mean "enjoyed"! What do you make of that?

> Of note, GABA isn't routinely inhibitory. It can sometimes reverse dopamine induced inhibition (evidenced by the fact that benzodiazepine often augment antipsychotics in the treatment of schizophrenia).
>

Well, as far as I know, GABA is inhibitory in its direct effect on the postsynaptic neuron. It does inhibit dopaminergic inhibition of the NAc, but it does so by inhibiting VTA dopamine neurons.

> I have read the research on GABA with regards to the blood brain barrier, but I'm also saying that it has an effect. I don't buy the notion that my blood brain barrier is 'dysfunctional' but that there is likely an alternative explanation for how it works.
>

I don't know much about the details of how the BBB works, but I do know that most neurotransmitters (including dopamine, noradrenaline, and serotonin) do not cross the BBB.

> Research on GABA not crossing the blood brain barrier is somewhat limited (and restricted to animals), so it is possible that it partially crosses. I am not a biologist but am a bit confused as to why picamilon (GABA bound to niacin) ostensibly readily crosses the blood brain barrier while a smaller portion of that molecule (i.e. gaba) does not.
>

It's not just about size; polarity and lipophilicity play a role too. In addition, there is active transport of select molecules (eg. tyrosine, tryptophan) across.

-undopaminergic


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poster:undopaminergic thread:1109574
URL: http://www.dr-bob.org/babble/20200303/msgs/1109606.html