Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: does anyone know about GABA receptors

Posted by undopaminergic on April 14, 2020, at 7:26:24

In reply to Re: does anyone know about GABA receptors, posted by linkadge on April 13, 2020, at 13:02:14

> >dopamine in the nucleus accumbens (NAc) are >inhibitory, or in other words, the VTA dopaminergic >neurons inhibit the shell of the NAc to produce its >rewarding effects.
> Right. Research points to the notion that dopamine is more involved in reward anticipation, rather than reward itself.

I agree it is mostly anticipatory. The emotion it produces can be called "desire" or "wanting"; desire to pursue something perceived as rewarding. With stimulants, there is no increase in consummatory reward ("liking", "enjoying"). However, the desire (or "lust" or "enthusiasm") *is* rewarding in its own right.

That said, pramipexole was anti-anhedonic for me. I enjoyed music, food, and movies, in a way I hadn't since the depression started and until I tried pramipexole; and I do mean "enjoyed"! What do you make of that?

> Of note, GABA isn't routinely inhibitory. It can sometimes reverse dopamine induced inhibition (evidenced by the fact that benzodiazepine often augment antipsychotics in the treatment of schizophrenia).

Well, as far as I know, GABA is inhibitory in its direct effect on the postsynaptic neuron. It does inhibit dopaminergic inhibition of the NAc, but it does so by inhibiting VTA dopamine neurons.

> I have read the research on GABA with regards to the blood brain barrier, but I'm also saying that it has an effect. I don't buy the notion that my blood brain barrier is 'dysfunctional' but that there is likely an alternative explanation for how it works.

I don't know much about the details of how the BBB works, but I do know that most neurotransmitters (including dopamine, noradrenaline, and serotonin) do not cross the BBB.

> Research on GABA not crossing the blood brain barrier is somewhat limited (and restricted to animals), so it is possible that it partially crosses. I am not a biologist but am a bit confused as to why picamilon (GABA bound to niacin) ostensibly readily crosses the blood brain barrier while a smaller portion of that molecule (i.e. gaba) does not.

It's not just about size; polarity and lipophilicity play a role too. In addition, there is active transport of select molecules (eg. tyrosine, tryptophan) across.





Post a new follow-up

Your message only Include above post

Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.


Start a new thread

Google www
Search options and examples
[amazon] for

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:undopaminergic thread:1109574