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Re: does anyone know about GABA receptors

Posted by undopaminergic on April 14, 2020, at 10:20:45

In reply to Re: does anyone know about GABA receptors undopaminergic, posted by linkadge on April 14, 2020, at 9:50:58

> >until I tried pramipexole; and I do mean "enjoyed"! >What do you make of that?
>
> My theory is that the drug first creates reward anticipation (supressing the NAc to initiate the hunt for reward) and also enhances the cognitive processes involved in obtaining the reward (thinking, concentration, planning). As the drug leaves the system the NAc begins firing again resulting in some level of satisfaction with what has been accomplished. Just a theory.
>

I'm not sure I understand. I did not have to wait to reap the satisfaction till the drug had left the system. Also, these things (eg. listening to music) I enjoyed did not require much cognition at all.

Could it be that dopamine D3 somehow activates endogenous opioids? Or other reward mechanisms.

-undopaminergic


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