Psycho-Babble Medication | about biological treatments | Framed
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Re: does anyone know about GABA receptors

Posted by linkadge on April 13, 2020, at 13:02:14

In reply to Re: does anyone know about GABA receptors, posted by undopaminergic on April 13, 2020, at 9:11:21

>dopamine in the nucleus accumbens (NAc) are >inhibitory, or in other words, the VTA dopaminergic >neurons inhibit the shell of the NAc to produce its >rewarding effects.

Right. Research points to the notion that dopamine is more involved in reward anticipation, rather than reward itself.

Of note, GABA isn't routinely inhibitory. It can sometimes reverse dopamine induced inhibition (evidenced by the fact that benzodiazepine often augment antipsychotics in the treatment of schizophrenia).

I have read the research on GABA with regards to the blood brain barrier, but I'm also saying that it has an effect. I don't buy the notion that my blood brain barrier is 'dysfunctional' but that there is likely an alternative explanation for how it works.

Research on GABA not crossing the blood brain barrier is somewhat limited (and restricted to animals), so it is possible that it partially crosses. I am not a biologist but am a bit confused as to why picamilon (GABA bound to niacin) ostensibly readily crosses the blood brain barrier while a smaller portion of that molecule (i.e. gaba) does not.

But again, to people who doubt it has a function just need to try it (of course, only if they want).





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