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Re: does anyone know about GABA receptors

Posted by undopaminergic on April 13, 2020, at 9:11:21

In reply to Re: does anyone know about GABA receptors undopaminergic, posted by linkadge on April 13, 2020, at 8:01:01

> It's a good question. Normally I defer to the experts but having taken GABA on and off, there is absolutely an effect.
>
> Some theories as to how / why include:
>
> - some GABA may cross the BBB
> - may be altering gut bacteria positively
> - muscle relaxant effects of GABA in periphery
> - may affect lower brainstem / vagal nerve
>
> Not sure. All I can say is try it. It does have an effect. Not quite as potent as picamillon.
>
> Linkadge
>

What he's saying is that if it does have an effect for you, then your BBB isn't up to standard. The other reasons that you mention are plausible, but he doesn't address them.

I don't have a reason to use it myself. If I do need more inhibitory neurotransmission, I would want D2-, D3-, and/or D4-dopaminergic agonism. Speaking of which, it is interesting to note that the pleasing effects of dopamine in the nucleus accumbens (NAc) are inhibitory, or in other words, the VTA dopaminergic neurons inhibit the shell of the NAc to produce its rewarding effects.

-undopaminergic


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URL: http://www.dr-bob.org/babble/20200303/msgs/1109596.html