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Re: does anyone know about GABA receptors

Posted by undopaminergic on April 16, 2020, at 7:56:42

In reply to Re: does anyone know about GABA receptors, posted by linkadge on April 14, 2020, at 18:33:59

> >I did not have to wait to reap the satisfaction >till the drug had left the system. Also, these >things (eg. listening to music) I enjoyed did not >require much cognition at all.
> Yeah. Who knows, but I hear what you're saying. For me ritalin is a bit rewarding in the sense that it kills the noise in my head (creating a feeling of peace / control).

That is the so-called "paradoxical calming" response to stimulants in people with ADHD. I don't get that with methylphenidate, but I did with phenylethylamine for the first few doses. I agree the feeling of calm and control is rewarding in a way, but not quite the same way as the tranquility you can feel with opioids. Of course, attention is also improved with the calm and silence, which reduces inner distraction. I also found that in this state, short-term memory was much improved, but it was probably secondary to the improved attention.

> For music, it could be that dopamine creates a degree of synchronization that aids in the appreciation of music. It may too depend on your baseline serotonin levels.

Why serotonin?

I found the music actually *sounded* better, not just that I enjoyed it more. Colours were more vivid, and food and drink tasted better.

Dopamine is also linked to salience. Certainly the music was more salient, but there was more to it than that.





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