Posted by linkadge on March 26, 2016, at 17:46:51
In reply to Re: Tricyclics quick acting?? » B2chica, posted by SLS on March 24, 2016, at 13:48:18
Amitriptyline has some very interesting qualities.
For instance, amitriptyline is the only antidepressant which directly binds to the same receptors as BDNF. In other words, in depression, if BDNF is low, amitriptyline can activate the exact same receptors to produce neurogenesis.
If you are coming from mixed states, you will likely not stabilize overnight. You may need adjustments of a mood stabilizer.
I would recommend going slower with the doses if you are experiencing mixed states - say 10mg for the first week - at least. Amitriptyline is a powerful antidepressant, but it can take some time - especially to adjust to side effects.
I have noticed sometimes that if irritability is replacing anxiety, this can be a good thing - as long as it subsides. This can be a sign that your brain is rebalancing fear with aggression.
Linkadge
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URL: http://www.dr-bob.org/babble/20160306/msgs/1087577.html