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Re: Tricyclics and bipolar depression

Posted by linkadge on March 21, 2016, at 18:27:13

In reply to Re: Tricyclics and bipolar depression » linkadge, posted by SLS on March 21, 2016, at 12:32:18

Drugs which block 5-ht2 receptors are known to improve sleep. Blocking 5-ht2 receptors blocks the serotonin induced supression of melatonin, and may help offset the circadian shifts associated with excessive nighttime light. 5-ht2 receptors appear to interact with GSK-3.

For instance, 5-ht2 blockers can improve disrupted sleep patterns in mice lacking monoamine oxidase.

Also, the histamine and calcium channel blocking effects of cyproheptadine can also improve sleep.

Linkadge



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poster:linkadge thread:1087318
URL: http://www.dr-bob.org/babble/20160306/msgs/1087410.html