Posted by linkadge on March 28, 2016, at 10:16:26
In reply to Re: Tricyclics quick acting?? » linkadge, posted by SLS on March 27, 2016, at 6:36:15
Hi SLS,
You can google "amitriptyline + trk-b"
Amitriptyline potently binds to the trk-b receptor. BDNF is the natural ligand for trk-b. Interestingly, it also binds to the trk-a receptor (for which NGF is the natural ligand)
No other TCAs have this property. Although, they may increase BDNF via monoaminergic mechanisms. This is interesting for amitriptyline however, as it doesn't require any time delay for activation of the BDNF pathways.
Linkadge
poster:linkadge
thread:1087318
URL: http://www.dr-bob.org/babble/20160306/msgs/1087607.html