Posted by linkadge on March 13, 2016, at 19:33:20
In reply to Re: methylation hypothesis » Larry Hoover, posted by linkadge on March 13, 2016, at 18:49:10
I did a 20 min crash course on Wikipedia:
I gathered the following:
-Histones prevent gene transcription
-Acetylated histones are less able to bind less to DNA to prevent transcription
-Histone deacetylase HDAC removes acetyl groups from histone allowing them to more effectively prevent gene transcription
-HDAC inhibitors block histone deacetylase, which reduces histone deacetylation, which allows more acetyl groups on this histone, which makes the histones less able to bind to DNA to prevent gene transcription** Net effect of HDAC inhibitors is to enhance gene transcription
Methylation is related to deactylation in that they both result in more condensed DNA (which reduces gene transcription).
HDAC inhibitors can thus inhibit the reduction in gene transcription brought on by DNA methylation.
But, if methylation decreases gene transcription, how does this improve depression?
I know nothing.Linkadge
poster:linkadge
thread:1087015
URL: http://www.dr-bob.org/babble/20160306/msgs/1087115.html