Posted by linkadge on March 11, 2016, at 21:32:34
In reply to Re: Trying methylfolate, posted by SLS on March 11, 2016, at 17:19:30
I understand that overmethylation can reduce the expression of the reelin gene. Reelin has effects on neurogenesis, synaptic density and cell to cell connections.
From Wikipedia:
"Reelin has been suggested to be implicated in pathogenesis of several brain diseases. The expression of the protein has been found to be significantly lower in schizophrenia and psychotic bipolar disorder, but the cause of this observation remains uncertain as studies show that psychotropic medication itself affects reelin expression. "
Valproate can reduce some of the hypermethylation of the reelin gene that may be present in certain models of schizophrenia / bipolar.
Article: Reelin promoter methylation in Schizophrenia...
http://www.ncbi.nlm.nih.gov/pubmed/15961543
Linkadge
poster:linkadge
thread:1087015
URL: http://www.dr-bob.org/babble/20160306/msgs/1087061.html