Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: methylation hypothesis » linkadge

Posted by linkadge on March 14, 2016, at 19:50:37

In reply to Re: methylation hypothesis » SLS, posted by linkadge on March 14, 2016, at 19:35:00

Here is an interesting study in which amitriptyline and valproate are shown to induce different degrees of gene demethylation (in different brain regions). Interestingly, valproate induced demethylation strongly at GLT-1 (glutamate transporter) whereas amitriptyline did not. This would be expected to result in increased activity of the glutamate transporter after valproate administration (functioning enhancing glutamate reuptake).

http://www.nature.com/npp/journal/v35/n3/full/npp2009188a.html

This is interesting. We know so little about the widespread effects of these drugs. Just because the drug directly affects one target, does not mean that other targets, modified more slowly by changes to gene transcription, are not the more active targets.

Linkadge


Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:linkadge thread:1087015
URL: http://www.dr-bob.org/babble/20160306/msgs/1087141.html