Posted by sigismund on August 17, 2010, at 17:16:44
In reply to Re: Treatment Resistant Depression. » ed_uk2010, posted by europerep on August 17, 2010, at 14:16:04
That was all very interesting.
Certainly what you say here.........
>. it DID work in the beginning, and that was NOT due to the general opioid euphoria.. this euphoria is mu-receptor-mediated, and buprenorphine plasme levels peak at 45min to 1 hour after intake (sublingual).. also, "recreational" users say the effect is strongest at about an hour.. my improvement started some 4-5 hours after taking it - and subsided some 4-5 hours later.
is broadly consistent with what people on bupe maintenance report as compared with methadone maintenance...that it is less depressing.
As you would know, a proportion of such people are self-medicating for depression.
poster:sigismund
thread:958488
URL: http://www.dr-bob.org/babble/20100811/msgs/958943.html