Posted by europerep on August 18, 2010, at 14:22:44
In reply to Re: Treatment Resistant Depression., posted by linkadge on August 17, 2010, at 20:11:55
> The tcas also have kappa agonism and NMDA antagonism. This might produce an anti-tollerance effect.
>
kappa-agonism is bad though.. well, talk about reductionism, but, in general kappa-agonism produces dysphoria.. that's why the development of kappa agonists for non-mu-pain medication was not pursued.. kappa-antagonism may be good, well it very probably is, and guess what, buprenorphine is a kappa-antagonist..also, what I forgot to say yesterday, going down from 9mg to doses less than a mg in rather quick steps produced absolutely no withdrawal in me.. I wanted to get rid off it even quicker to start a new med, but I told myself to be patient, not take a risk of withdrawal and not disturb my endogenous opioids too much by quitting all at once..
poster:europerep
thread:958488
URL: http://www.dr-bob.org/babble/20100811/msgs/959054.html