Re: Opiates as sigma agonists

Posted by linkadge on August 15, 2010, at 21:23:25

In reply to Re: Treatment Resistant Depression. » bleauberry, posted by ed_uk2010 on August 15, 2010, at 13:50:28

Opiates like codiene and morphine act as fairly potent sigma-1r agonists. Sigma agonists have documented antidepressant, anxiolytic and cognitive enhancing effects.
Whose to say that the "AD" effect of opiates is not related to other targets of select opiates?
As eluded to, some studies suggest increased opioid like activity in depression. Socially defeated "depressed" animals show increased MU opioid neurotransmission.
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Treatment Resistant Depression. bleauberry 8/13/10
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Re: Treatment Resistant Depression. » sigismund sigismund 8/13/10
Re: Treatment Resistant Depression. » bleauberry floatingbridge 8/14/10
Re: Treatment Resistant Depression. » linkadge SLS 8/14/10
Re: Treatment Resistant Depression. » linkadge bleauberry 8/14/10
Re: Treatment Resistant Depression. » ed_uk2010 bleauberry 8/14/10
Re: Treatment Resistant Depression. » floatingbridge bleauberry 8/14/10
Re: Treatment Resistant Depression. » bleauberry ed_uk2010 8/14/10
Re: Treatment Resistant Depression. » ed_uk2010 sigismund 8/14/10
Re: Treatment Resistant Depression. emmanuel98 8/14/10
Re: Treatment Resistant Depression. » ed_uk2010 bleauberry 8/15/10
Re: Treatment Resistant Depression. » bleauberry ed_uk2010 8/15/10
Re: Treatment Resistant Depression. linkadge 8/15/10
Re: Opiates as sigma agonists linkadge 8/15/10
Re: Opiates as sigma agonists » linkadge Phillipa 8/15/10
Re: Opiates as sigma agonists » linkadge SLS 8/16/10
Re: Opiates as sigma agonists » SLS violette 8/16/10
sls, link + violette: Opiates as sigma agonists floatingbridge 8/16/10
Re: Opiates as sigma agonists » SLS sigismund 8/16/10
Re: Opiates as sigma agonists » violette sigismund 8/16/10
Re: Treatment Resistant Depression. » sigismund ed_uk2010 8/16/10
Re: Treatment Resistant Depression. » ed_uk2010 sigismund 8/16/10
Re: SSRIs don't raise serotonin anyway linkadge 8/16/10
Re: Treatment Resistant Depression. » ed_uk2010 europerep 8/17/10
Re: Treatment Resistant Depression. » europerep sigismund 8/17/10
Re: Treatment Resistant Depression. linkadge 8/17/10
...
Re: Treatment Resistant Depression. » weatherfreak Phillipa 8/25/10

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