Posted by bleauberry on August 15, 2010, at 12:06:34
In reply to Re: Treatment Resistant Depression. » bleauberry, posted by ed_uk2010 on August 14, 2010, at 8:58:20
I agree with everything you have said. In fact, everything stated could apply equally as well to a discussion of any other neurotransmitter or drug. But all that was off the path. It appears that the primary body of the message was completely missed. Took some sidepaths and completely lost the main road.
> >Some people become dysphoric. They don't need more endorphins help.
>
> Some of the people who become dysphoric after a single dose become euphoric after repeated doses. In the same way that response to an SSRI does not prove that a person has serotonin deficiency, response to an opioid does not prove that a person has endorphin deficiency. It's unwise to presume that we understand so much.
>
> >Other people however go from depressed to normal...pure normal...not high, not drugged, not euphoric, just plain normal...THAT is an easy diagnosis.
>
> It's not a diagnosis, it's an assumption - an assumption that endorphin deficiency is the underlying problem. Again, it is unwise to presume that we understand the mechanisms behind such a response. Unfortunately, an excellent acute response to an opioid does not mean that the benefits will last. They might do, or they might not. I think that's the same with just about everything ie. the long term response it impossible to predict with any accuracy.
>
> >Except that...LDN or DLPA have a very high likelihood of coming close to the same result...
>
> I doubt that a response to Vicodin can predict response to LDN or DLPA. LDN, opioid agonists and DLPA have different mechanisms of action. A response to Vicodin might predict a response to say, oxycodone, because these drugs have the same mechanism of action.
>
> >That same patient staying instead with the ssris, antipsychotics, and mood stabilzers, is probably going to remain ill for a long time.
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> I fully understand the need for new and novel treatments for psychiatric illness. I do not dispute that.
>
> I think you have a tendency to present theory as if it were fact. This is what I disagree with.
>
poster:bleauberry
thread:958488
URL: http://www.dr-bob.org/babble/20100811/msgs/958674.html