Posted by ed_uk2010 on August 14, 2010, at 8:58:20
In reply to Re: Treatment Resistant Depression. » ed_uk2010, posted by bleauberry on August 14, 2010, at 8:25:18
>Some people become dysphoric. They don't need more endorphins help.
Some of the people who become dysphoric after a single dose become euphoric after repeated doses. In the same way that response to an SSRI does not prove that a person has serotonin deficiency, response to an opioid does not prove that a person has endorphin deficiency. It's unwise to presume that we understand so much.
>Other people however go from depressed to normal...pure normal...not high, not drugged, not euphoric, just plain normal...THAT is an easy diagnosis.
It's not a diagnosis, it's an assumption - an assumption that endorphin deficiency is the underlying problem. Again, it is unwise to presume that we understand the mechanisms behind such a response. Unfortunately, an excellent acute response to an opioid does not mean that the benefits will last. They might do, or they might not. I think that's the same with just about everything ie. the long term response it impossible to predict with any accuracy.
>Except that...LDN or DLPA have a very high likelihood of coming close to the same result...
I doubt that a response to Vicodin can predict response to LDN or DLPA. LDN, opioid agonists and DLPA have different mechanisms of action. A response to Vicodin might predict a response to say, oxycodone, because these drugs have the same mechanism of action.
>That same patient staying instead with the ssris, antipsychotics, and mood stabilzers, is probably going to remain ill for a long time.
I fully understand the need for new and novel treatments for psychiatric illness. I do not dispute that.
I think you have a tendency to present theory as if it were fact. This is what I disagree with.
poster:ed_uk2010
thread:958488
URL: http://www.dr-bob.org/babble/20100811/msgs/958562.html