Posted by bleauberry on August 14, 2010, at 8:06:05
In reply to Re: Treatment Resistant Depression., posted by linkadge on August 13, 2010, at 19:42:23
I totally agree with you LInk. The things you mentioned though are so hard, if not impossible, to identify, diagnose, or validate. But doing all that with the endorphin system, well, even a caveman could do it. My point is I don't get it...why all the hoopla on selected neurotransmitters as if they were everything there is in depression...but no mention of the big player endorphins. And no mention of all the things you listed either. Instead, keep pounding the serotonin-n-friends drugs despite they fail one after another after another. Kind of like trying to sift for gold in about a 10 foot area of a stream but not daring to go further upstream or downstream. So what if you can't find any gold in that 10 feet, keep looking there. Ya know? I'm just saying the endorphin system is a big player but that unlike the other systems it is very easy to test.
> I think its more complicated than that. I think that TRD is more hardwired.
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> "You can mess around all you want with serotonin, norepinephrine, dopamine etc. but if you don't have the right circutry in place, its not going to do anything" - a quote by Dr. Manjii.
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> I think TRD is probably related to mitochondrial decay, glial reductions, prefronal atrophy, decreased limbic interconnectivity, enlarged amygdala volume, decreased cortical grey matter, white matter hyperintensities, vascular insufficiancy etc. etc.
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> I personally think its a myth to believe that some magic chemical is going to come along and make it all better. It may take years of rehabilitative therapty for the brain to overcome such alterations.
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> Linakadge
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poster:bleauberry
thread:958488
URL: http://www.dr-bob.org/babble/20100811/msgs/958553.html