Posted by psychobot5000 on December 23, 2008, at 16:46:37
In reply to Re: Agomelatin: could 5HT(2c) action be bad for sl, posted by linkadge on December 23, 2008, at 9:35:47
> Theres more than that which could be considered ideal.
>
> For instance, there are some compounds with 5-ht uptake inhibition and 5-ht1a/b autoreceptor antagonism which apprently bypass the need for long term drug administration to desensitize these receptors.
>
>Suppose we take this in a slightly different direction: What might be the properties of an 'ideal' agent (acting on 5HT receptors) to be combined with a serotonin-reuptake -enhancer-, rather than an SSRI? 5HT1a agonism? Something else? Mightn't one make a more effective or targeted drug combination by -reducing- synaptic serotonin, and then targeting certain specific receptor subgroups for -increased- action, rather than the reverse?
(disclaimer: I am a tianeptine loyalist)
poster:psychobot5000
thread:869924
URL: http://www.dr-bob.org/babble/20081223/msgs/870527.html