Posted by Marty on December 23, 2008, at 9:51:29
In reply to Re: Agomelatin: could 5HT(2c) action be bad for sl » Marty, posted by SLS on December 23, 2008, at 7:16:15
> Interesting.
>http://www.nature.com/npp/journal/v28/n2/full/130>0057a.htmlYes, great paper indeed. Makes me think the team who develop Trazodone were on a good track: 5-HT2a antagonist, 5-HT2c agonist (via m-CPP) AND some SRI. If it wasn't of the side effects, in particular the hangover, and if the SRI was stronger it could be an awesome antidepressant if you embrace the thesis discussed in your paper.
That, said I wonder if my Agomelatine/Trazodone combo isn't working against each other in some way s while being completive in others. That paper suggest it would somehow, or did I badly interpret ? (I just woke up, my eyes are still glued)
Something happened yesterday that made me wonder even more: I took Agomelatine and .25mg Clonazepam but forgot to take my other meds (Trazo, Wellbutrin, Lamictal, Chromium).. 1 hour later I feel good and go to bed. Time pass by and I'm still not sleeping completely (unusual for me) but I wasn't caring because I was feeling GREAT.. even better than since I started Agomelatine. After a while I got up to go to the bathroom and realized how terrific I was feeling and when going back to my bed I saw on my desk the pills I forgot to take... and so I took them. This morning I wake up feeling not that great.. just normal hangover from Trazo and while I want to go out of the bed and do something of my day (this wasn't the case before Agomelatine) I don't feel excited about life like I do when I take Agomelatine alone...
While I strongly believe the thesis of the paper you sent me, my beliefs in my Ago/Trazo combo are shaky right now. I'm wondering if I should try reducing Trazodone .. in the last 3 days I realized my Agomelatine miracle wasn't 'constant' (consistency of Ago effect is a recurring theme in discussion between people who are currently on it BTW)
I scratch my head over this today. If you have an opinion whatsoever, even if the strong, I'm interested.
> To produce a treatment - whether monotherapy or >polypharmacy - that will inhibit the reuptake of >5-HT and simultaneously antagonize 5-HT2a and 5->HT2c receptors in the absence of DA antagonism >might be ideal to treat depression.I think it's a great strategy for a lot of people. But I'm still not sure about which are the best complement to 5-HT2a antagonism.. 5-HT2c antagonism OR agonism ? Linkage seems to eat for breakfast the right kind of papers lately to express an interesting opinion. I've ask him in my last post on this thread. What about yours ?
> I hate when researchers feel it necessary to
>search for a single molecule that will combine
>all the relevant mechanisms of action. Just give
>us multiple drugs that are highly specific,
>complementary, and synergistic.So do I. I wish our 'drug palette' would be more complete and specific. I feel the day we'll have the likes of 5-HT5/6/7 agonists, for example, developed and marketed is far, far away.
/\/\arty
Again, sorry for the long post.. hope you're good are reading diagonally. ;)
poster:Marty
thread:869924
URL: http://www.dr-bob.org/babble/20081223/msgs/870451.html