Posted by linkadge on December 23, 2008, at 9:35:47
In reply to Re: Agomelatin: could 5HT(2c) action be bad for sl » Marty, posted by SLS on December 23, 2008, at 7:16:15
Theres more than that which could be considered ideal.
For instance, there are some compounds with 5-ht uptake inhibition and 5-ht1a/b autoreceptor antagonism which apprently bypass the need for long term drug administration to desensitize these receptors.
If you take into acount the mood modulating effects of all 5-ht receptors you'd have some agent which might do the following:5-ht1a/b post synaptic agonism
5-ht1a/b autoreceptor antagonism
5-ht2a/c antagonism
5-ht3 antagonism
5-ht4 agonism
5-ht7 antagonism+ 5-ht uptake inhibition (or not)
etc. etc.
(but I still don't think that 5-ht uptake inhibition is at all relatant to the antidepressant effects of SSRI's.Linkadge
poster:linkadge
thread:869924
URL: http://www.dr-bob.org/babble/20081223/msgs/870443.html