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Re: Agomelatin: could 5HT(2c) action be bad for sl

Posted by linkadge on December 23, 2008, at 9:35:47

In reply to Re: Agomelatin: could 5HT(2c) action be bad for sl » Marty, posted by SLS on December 23, 2008, at 7:16:15

Theres more than that which could be considered ideal.

For instance, there are some compounds with 5-ht uptake inhibition and 5-ht1a/b autoreceptor antagonism which apprently bypass the need for long term drug administration to desensitize these receptors.


If you take into acount the mood modulating effects of all 5-ht receptors you'd have some agent which might do the following:

5-ht1a/b post synaptic agonism
5-ht1a/b autoreceptor antagonism
5-ht2a/c antagonism
5-ht3 antagonism
5-ht4 agonism
5-ht7 antagonism

+ 5-ht uptake inhibition (or not)

etc. etc.


(but I still don't think that 5-ht uptake inhibition is at all relatant to the antidepressant effects of SSRI's.

Linkadge


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URL: http://www.dr-bob.org/babble/20081223/msgs/870443.html