Posted by SLS on December 23, 2008, at 7:16:15
In reply to Re: Agomelatin: could 5HT(2c) action be bad for sl » SLS, posted by Marty on December 21, 2008, at 15:08:00
Hi Marty.
Interesting.
http://www.nature.com/npp/journal/v28/n2/full/1300057a.html
To produce a treatment - whether monotherapy or polypharmacy - that will inhibit the reuptake of 5-HT and simultaneously antagonize 5-HT2a and 5-HT2c receptors in the absence of DA antagonism might be ideal to treat depression.
I hate when researchers feel it necessary to search for a single molecule that will combine all the relevant mechanisms of action. Just give us multiple drugs that are highly specific, complementary, and synergistic.
- Scott
poster:SLS
thread:869924
URL: http://www.dr-bob.org/babble/20081223/msgs/870431.html