Posted by linkadge on December 21, 2008, at 22:08:33
In reply to Re: Agomelatin: could 5HT(2c) action be bad for sl » SLS, posted by Marty on December 21, 2008, at 13:10:35
Too much frontal cortex activity can actually cause a certain form of depression too.
Certain depressive states are associated with frontal cortex hyperactivity.
Also, the 5-ht2c receptors exert anticonvulsant effects. Too much 5-ht2c antagonism could decrease the seizure threshhold. For instance, 5-ht2c antagonism can increase the convulsant effects of cocaine. You may want to watch with the combination of a 5-ht2c antagonist and bupriopion (on a theoretic level). Too much 5-ht2c antagonism apparently can cause agression too. Remeron rage is probably due to a combination of the 5-ht2c antagonism and alpha-2 antagonism. 5-ht2c receptors also exert some effects on neurogenesis. 5-ht2c receptor antagonists block the neurotrophic effects of serotonin in certain hippocampal subfields.
The 5-ht2c receptors also control appetite. Too much 5-ht2c antagonism could lead to an inability to supress appetite.
Actually, if I recall, agomelatine is also a 5-ht2b antagonist. This might be good to take in combination with trazodone since mcpp is a 5-ht2b antagonist and could have negative hypertrophic effects on cardiac valvles.
Just thinking aloud.
Linkadge
poster:linkadge
thread:869924
URL: http://www.dr-bob.org/babble/20081214/msgs/870191.html