Posted by Marty on December 21, 2008, at 13:10:35
In reply to Re: Agomelatin: could 5HT(2c) action be bad for sl » Marty, posted by SLS on December 21, 2008, at 5:28:33
Hi Scott,
> How do you think one would respond to a drug that antagonizes 5-HT2a/b/c ?
Coming from you, I'd guess you have something in mind asking me this catch-21 question ... ;) As you know, many drugs antagonize those 3 and many feel different from each others.
I'd think that a selective 5-HT2a, 2b and 2c antagonist without any other affinity for other receptors/transporter ESPECIALLY anything related to DA, could be a great drug -for a subset- of depression/anxiety afflicted. The increased tendency in the last couple years of neuroleptic prescription for depression/anxiety is, IMO, hinting at this potential. The only problem with those, again IMO, is mainly DA antagonism. While it works great for some, most are let down because of the -DA effect and others non 5-HT2 antagonism action.
Is the perfect 5-HT2a,b,c would be any good for treatment resistant people ? I doubt it. But that said, it's pretty good for the subset of treatment intolerant people as it comes with very few side-effects compared to much everything else when prescribed at low dose. Treatment intolerants being very sensitive to drugs (all effects, not only the undesirable one), that low dose would likely be sufficient for a good proportion of them.
In any case, it's working great for me as I consider myself in total remission, ZERO side effects since a couple days and the core of my combo is 5-HT2a,b,c antagonism, a combo I designed with frontal cortex focalized +DA/NE tonic enhancement by way of DA neurons disinhibition rather than too much brutal DA/NE reuptake inhibition:
Agomelatine 25 mg : 5-HT2c antagonism / cortico frontal +DA/NE.
Trazodone 50 mg : 5-HT2a/b(c) antagonism / orbitofrontal +DA
Wellbutrin 100 mg at night : NE/DA RI enhancing the frontal cortex focalized pro-DA effect of the 2 first I guess.
Lamictal 100 mg and Clonazepam .25 : for good mesure .. without them I think I may not be able to handle the +DA/+NE in some regions which directly or indirectly leads to increased anxiety in my type.
My design was probably flawed to many extent regarding what I wanted to modulate and how I planned my cocktail would succeed, but in any case the effects are exactly the one I was 'dreaming of' and I can't care less if I'm only a dumb lucky bastard. :P
And, you.. what's your feeling about 5-HT2 'triple subtype antagonism' ?
/\/\arty
poster:Marty
thread:869924
URL: http://www.dr-bob.org/babble/20081214/msgs/870059.html