Posted by psychobot5000 on January 23, 2009, at 15:50:30
In reply to Re: Agomelatine effects on OCD... » desolationrower, posted by SLS on January 23, 2009, at 2:45:48
Did a google search and found this on an odd site which doesn't give its research sources. I haven't the time to find a better source, but I've read very similar things elsewhere recently. This one is better, though because it has a list of the neurological targets involved in OCD, segregated by their positive or negative correlation with OCD symptoms. Though I'm assuming much of their conclusions are unconfirmed, it makes me wonder what might be done with all this information to throw together a makeshift treatment or two. If I come up with anything, I'll mention it.
http://www.k12academics.com/ocd_neuropsychiatry.htm
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"OCD primarily involves the brain regions of the striatum and the cingulate cortex, especially the striatum. OCD involves several different receptors, mostly H2, M4, nk1, NMDA, and non-NMDA glutamate receptors. The receptors 5-HT1D, 5-HT2C, and the mu opioid receptor exert a secondary effect. The H2, M4, nk1, and non-NMDA glutamate receptors are active in the striatum, whereas the NMDA receptors are active in the cingulate cortex.The activity of certain receptors is positively correlated to the severity of OCD, whereas the activity of certain other receptors is negatively correlated to the severity of OCD. Those correlations are as follows:
Activity positively correlated to severity:
H2
M4
nk1
non-NMDA glutamate receptorsActivity negatively correlated to severity:
NMDA
mu opioid
5-HT1D
5-HT2CThe central dysfunction of OCD involves the receptors nk1, non-NMDA glutamate receptors, and NMDA, whereas the other receptors exert secondary modulatory effects.
Pharmaceuticals that act directly on those core mechanisms are aprepitant (nk1 antagonist), riluzole (glutamate release inhibitor), and tautomycin (NMDA receptor sensitizer). The drugs that are popularly used to fight OCD lack efficacy because they do not act upon the core mechanisms."
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poster:psychobot5000
thread:869924
URL: http://www.dr-bob.org/babble/20090104/msgs/875649.html