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Re: bear with me... » pulse

Posted by linkadge on June 19, 2006, at 18:03:07

In reply to Re: bear with me... » linkadge, posted by pulse on June 18, 2006, at 20:26:07

Were you augmenting an SSRI with methyphenidate ?

I did notice some crashing, but it wasn't too bad for me.

Although ritalin is compared to cocaine, it isn't completely like it.

You can go to:

http://kidb.cwru.edu/pdsp.php

to look up compounds activities at certain targets. Lower Ki values mean greater affinity for the target.

Ie. Cocaine, 5-ht transporter ~150
DAT transporter ~300

Ritalin, 5-ht transporter ~5000
DAT transporter ~100

So, some authors speculate that the greater euphoria of cocaine is a combination of serotonin and dopamine transporter blockade.

Linkadge

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URL: http://www.dr-bob.org/babble/20060617/msgs/658829.html