Posted by linkadge on June 17, 2006, at 21:46:50
In reply to bear with me... » linkadge, posted by pulse on June 17, 2006, at 10:06:53
Yeah, I believe cocaine inhibits the uptake of all three monoamines, serotonin norepinephrine and dopamine.
But, I do believe it is a slightly stronger serotonin uptake inhibitor than dopamine or norepinephrine reuptake inhibitor.
Wellbutrin, otoh is really only a very weak dopamine uptake inhibitor, that is why it probably lacks abuse potential.
To kick cocaine, you might do well on prozac and methyphenidate. (Even methylphenidate is not as reinforcing/rewarding as cocaine, since it has minimal serotonin uptake inhibition). Methylphenidate does not consistently or readily substitiute for cocaine.
It is seeming that the rewarding properties of cocaine are a combination of its serotonin and dopamine uptake inhibition.
Linkadge
poster:linkadge
thread:655463
URL: http://www.dr-bob.org/babble/20060617/msgs/658158.html