Re: 2006 article » undopaminergic

Posted by Crotale on June 20, 2008, at 1:22:46

In reply to Re: 2006 article, posted by undopaminergic on June 4, 2008, at 4:11:14

> The article about buprenorphine for refractory It's not really accurate. The DEA focus on doctors prescribing large quantities of controlled substances, and whom they suspect not to be following reguladepression can be found by following one of the links listed in the message at:
> http://www.dr-bob.org/babble/20080528/msgs/831995.html
Dr Bodkin, who was the chief author of the article in question, was the consultant who originally suggested I try buprenorphine. This was back around 1996 or 1997.
> Another document - an editorial - mostly regarding the reasons why buprenorphine isn't likely to become an FDA-approved treatment for depression, can be found at:
> http://web.archive.org/web/20031118092749/http://www.sciencething.org/Callaway.pdf
Dr. Callaway's editorial is very much worth reading.
> Mu-agonism has a range of effects - some of them may be highly desirable, while others may be neutral or troublesome. Some effects will be noted only initially, while certain others will persist throughout treatment. Start at a low dose and titrate according to effect and tolerability.
I recommend starting at 0.15mg t.i.d. or p.r.n., based on personal experience.
> It is extremely unlikely that the DEA would target someone who prescribes buprenorphine once in a while.
I agree with this.
> Is is very safe, and while there's a definite risk of physical dependence, addiction is not likely - unless you have a propensity for abusing drugs - e.g. dissolving and injecting tablets.
Physical dependence is quite mild, although you should not discontinue it abruptly because of the risk of rebound depression.
It's safe enough that I believe it's considered the treatment of choice for pregnant drug addicts, and I don't think there have been any deaths from overdose (except possibly in combination with OD of benzodiazepines).
Crotale

Thread

stress, dynorphin, kappa opioid receptors linkadge 5/28/08
...
Re: stress, dynorphin, kappa opioid receptors » linkadge Phillipa 5/28/08
Re: stress, dynorphin, kappa opioid receptors linkadge 5/29/08
2006 article iforgotmypassword 6/3/08
Re: 2006 article undopaminergic 6/3/08
Re: 2006 article » undopaminergic iforgotmypassword 6/3/08
Re: 2006 article iforgotmypassword 6/3/08
wikipedia says: iforgotmypassword 6/3/08
Re: 2006 article undopaminergic 6/4/08
Re: 2006 article undopaminergic 6/5/08
wait, is naltrexone even a kappa antagonist? iforgotmypassword 6/6/08
Re: wait, is naltrexone even a kappa antagonist? undopaminergic 6/6/08
Re: salvia and kappa receptors linkadge 6/11/08
Re: 2006 article » undopaminergic Crotale 6/20/08
Re: stress, dynorphin, kappa opioid receptors jrbecker76 7/21/08
Re: salvia and kappa receptors » linkadge Questionmark 8/7/08

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