Posted by undopaminergic on June 3, 2008, at 13:06:15
In reply to 2006 article, posted by iforgotmypassword on June 3, 2008, at 10:15:59
> http://opioids.com/kappa/kappa-dopamine.html
>
> if kappa agonism can prevent dopaminergic projection into the prefrontal cortex, it may be a significant cause of executive functioning issues?
>Yes, I think so, and I've noted a remarkable improvement of executive function after adding buprenorphine - the most potent kappa-antagonist in clinical use - to my regimen of methylphenidate and guanfacine.
> (i want to try naltrexone, but i worry its lack of selectivity, and the fact that it is very old and concrete knowledge of it's carcinogenic potential is just not there, making the idea of long term use seem a bit creepy. sigh.)
>While I'm not particularly worried about its carcinogenic potential, I'm highly suspicious of its antagonism of mu-opioid receptors, as this may reduce dopamine release especially in the nucleus accumbens.
poster:undopaminergic
thread:831631
URL: http://www.dr-bob.org/babble/neuro/20080418/msgs/832695.html