stress, dynorphin, kappa opioid receptors

Posted by linkadge on May 28, 2008, at 11:04:07

So apparently kappa opioid receptor agonism can cause depression by inhibiting the release of dopamine in the neucleus accumbens.
Stress increases the levels of dynorphin in the neucleus accumbens which is a agonist at kappa opiod receptors.
Buprenorphine is a fairly potent kappa antagonist.
Exercise decreases dynorphin levels in the neucleus accumbens (antidepressant effect?)
Also the TCA's appear to decrease dynorphin levels.
Anyhow sounds like an interesting target for mood disorders. Anyone have any input?
Linkadge

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stress, dynorphin, kappa opioid receptors linkadge 5/28/08
Re: stress, dynorphin, kappa opioid receptors undopaminergic 5/28/08
Re: stress, dynorphin, kappa opioid receptors » linkadge Phillipa 5/28/08
Re: stress, dynorphin, kappa opioid receptors linkadge 5/29/08
2006 article iforgotmypassword 6/3/08
Re: 2006 article undopaminergic 6/3/08
Re: 2006 article » undopaminergic iforgotmypassword 6/3/08
Re: 2006 article iforgotmypassword 6/3/08
wikipedia says: iforgotmypassword 6/3/08
Re: 2006 article undopaminergic 6/4/08
Re: 2006 article undopaminergic 6/5/08
wait, is naltrexone even a kappa antagonist? iforgotmypassword 6/6/08
Re: wait, is naltrexone even a kappa antagonist? undopaminergic 6/6/08
Re: salvia and kappa receptors linkadge 6/11/08
Re: 2006 article » undopaminergic Crotale 6/20/08
Re: stress, dynorphin, kappa opioid receptors jrbecker76 7/21/08
Re: salvia and kappa receptors » linkadge Questionmark 8/7/08

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