Posted by undopaminergic on June 4, 2008, at 4:11:14
In reply to Re: 2006 article, posted by iforgotmypassword on June 3, 2008, at 18:10:51
>
> i see him on thursday. my mission is to gather articles or reliable reading material that would support a buprenorphine rx, or a naltrexone rx.
>The article about buprenorphine for refractory depression can be found by following one of the links listed in the message at:
http://www.dr-bob.org/babble/20080528/msgs/831995.htmlAnother document - an editorial - mostly regarding the reasons why buprenorphine isn't likely to become an FDA-approved treatment for depression, can be found at:
http://web.archive.org/web/20031118092749/http://www.sciencething.org/Callaway.pdf> my concern is that the ideal kappa antagonism from buprenorphine may not be acheivable without significant mu agonism. (opinions?) does it have any other receptor affinities to worry about?
>Mu-agonism has a range of effects - some of them may be highly desirable, while others may be neutral or troublesome. Some effects will be noted only initially, while certain others will persist throughout treatment. Start at a low dose and titrate according to effect and tolerability.
> looking on wikipedia, they mention:
> "However, psychological distress is currently not an approved indication for the use of any opioid, and legally it falls in a "grey zone" that is technically legal but a doctor could still face charges regardless (but not for off-label scripting in itself, simply being singled out by the USA's Drug Enforcement Administration (DEA), who prosecute doctors often for using controlled substances for approved uses ("too much")).[8][9]"
>
> whoever wrote that, are they making sense?
>It's not really accurate. The DEA focus on doctors prescribing large quantities of controlled substances, and whom they suspect not to be following regulations - e.g. being overly careless about whether the drugs prescribed seem likely to be abused or sold ("diverted"). If the doctor can provide credible justification and documentation for his practices, he/she is less likely to be prosecuted.
It is extremely unlikely that the DEA would target someone who prescribes buprenorphine once in a while.
>
> i'll have to find something supporting that it can be used safely without causing addiction.
>Is is very safe, and while there's a definite risk of physical dependence, addiction is not likely - unless you have a propensity for abusing drugs - e.g. dissolving and injecting tablets.
poster:undopaminergic
thread:831631
URL: http://www.dr-bob.org/babble/neuro/20080418/msgs/832834.html